Mycophenolate Mofetil

"we are what we eat" Gluten by James Keye Food is not benign. Mycophenolate mofetil It is the most powerful, mycophenolate mofetil chemically active material that we routinely put into our bodies, mycophenolate mofetil that is, mycophenolate mofetil the biochemical system upon which rides our consciousness order. Mycophenolate mofetil In fact, mycophenolate mofetil all food contains a quantity of risk: just look at the size and function of the liver to prove that. This essay could go from here in many directions; for example, mycophenolate mofetil to the chips and energy drinks that so many, mycophenolate mofetil especially the young, mycophenolate mofetil abuse themselves with or to the preparations that are used to create eating addictions, mycophenolate mofetil but this is about a personal concern suddenly turned timeless and potentially devastating. Someone dear to me has had continuing depressive symptoms (and I have dabbled in the depression waters for my knowing life). Mycophenolate mofetil He has tried diet related ameliorators: reducing pesticide in take; getting adequate and balanced amounts of essential amino acids, mycophenolate mofetil vitamins and micronutrients; generally recognizing the critical role of intake. My discussions with him had begun to move more and more often in the pharmacological direction, mycophenolate mofetil a “solution” we agreed that was like using a mallet to repair a fine Swiss chronograph. Mycophenolate mofetil But we had never seriously discussed gluten. Of course, mycophenolate mofetil gluten and celiac disease had come up, mycophenolate mofetil but it somehow didn’t seem directly relevant to symptoms of neurotransmitters. Mycophenolate mofetil However, mycophenolate mofetil as I bumped into more and more references to gluten digestion issues, mycophenolate mofetil I decided to just stop eating gluten as a self-test before I offered this as a serious option for my son. I have for many years kept track of my calorie budget and general diet (see first sentence!). Mycophenolate mofetil When I stopped eating foods containing gluten I replaced (or more than replaced) the calories with other foods (e.g., mycophenolate mofetil avocado for bread in some circumstances). Mycophenolate mofetil And yet, mycophenolate mofetil in the first 10 days I lost 7 pounds. Mycophenolate mofetil Now those who know basic metabolism realize that 7 pounds of fat represents over 25, mycophenolate mofetil000 calories and at 2000 calories a day, mycophenolate mofetil even if I ate nothing, mycophenolate mofetil I would only use up about 6 pounds of fat; ergo, mycophenolate mofetil the weight loss was from water, mycophenolate mofetil more precisely, mycophenolate mofetil edema; and even more precisely, mycophenolate mofetil the edema of an inflammatory response to gluten was the most likely reason. I was amazed. Mycophenolate mofetil As time passed my energy level increased. Mycophenolate mofetil Walking up steep hills, mycophenolate mofetil especially carrying weight, mycophenolate mofetil had become more and more taxing for me over the years; I had given this to my age. Mycophenolate mofetil But, mycophenolate mofetil even 3 weeks into the diet change I noticed a reliable difference. Mycophenolate mofetil And then I began to notice a change in mood. Mycophenolate mofetil I would call it an improvement certainly, mycophenolate mofetil though more correctly it was a smoothing out. About a month into gluten-free my car decided to malfunction many miles away from what passes here for civilization; this after I had been walking for some time in the high desert hills. Mycophenolate mofetil My only choices were to stay overnight or to walk out in the deep dusk and dark. Mycophenolate mofetil I walked out carrying my camera gear – 2½ hours before a road and a car kindly saved me. Mycophenolate mofetil But I was fine and fully prepared to walk the next 8 miles to home. Mycophenolate mofetil This would not have been my condition the month before. Mycophenolate mofetil My interest was fully piqued. Gluten: “Wheat gluten was traditionally classified into gliadin and glutenin based upon solubility in aqueous alcohol. Mycophenolate mofetil Gliadins were thought to be responsible for precipitating coeliac disease; glutenins were thought probably to be nontoxic. Mycophenolate mofetil More recent classification, mycophenolate mofetil according to primary amino acid structure, mycophenolate mofetil reveals not only great heterogeneity but also similarities between different gliadin and glutenin proteins. Mycophenolate mofetil Peptides derived from both groups are immunostimulatory in coeliac disease and it is highly probable that glutenin proteins are therefore toxic. Mycophenolate mofetil Attempts to breed wheat with satisfactory baking properties tolerated by coeliac patients will be very difficult.” (P. Mycophenolate mofetil D. Mycophenolate mofetil Howdle, mycophenolate mofetil St James’s University Hospital, mycophenolate mofetil Leeds, mycophenolate mofetil UK.) This is a stark statement. Gluten is a water insoluble protein complex found in the family of the grasses; it seems that its properties are useful in protecting seeds in dry conditions. Mycophenolate mofetil Thus, mycophenolate mofetil unlike many of the plant-made chemicals that are toxic in foods as a form of protection from predation, mycophenolate mofetil gluten’s consequences come from the unfamiliarity of the protein to the human digestive system, mycophenolate mofetil at least, mycophenolate mofetil the unfamiliarity of the Caucasian digestive system.1 In the most extreme form, mycophenolate mofetil celiac disease (US spelling), mycophenolate mofetil symptoms are dramatic, mycophenolate mofetil though often misdiagnosed. Mycophenolate mofetil But what interested me were the less intense consequences. Humans have been eating grass-based foods as a major and continuous part of their diet for only about 8 to 10 thousand years. Mycophenolate mofetil And even then it is only in very local regions that grains have been primary for that long. Mycophenolate mofetil Most of the world has only been grain-fed for less than a third of that time. Mycophenolate mofetil Our digestive system and the enzymes that are its tools have been evolving to a reasonably consistent diet for millions of years. Mycophenolate mofetil Prior to grains, mycophenolate mofetil the great change for our Genus was the addition of meat and animal fat in increasing amounts over the last 2½ to 2 million years. Mycophenolate mofetil The jump to grains has been dramatic and rapid – far too rapid to allow for digestive processes to adapt fully (or even at all) to new proteins. The consequence is that gluten can only be partially digested. Mycophenolate mofetil This is especially true for those with celiac disease. Mycophenolate mofetil It is now understood that their bodies treat certain of the peptide pieces (break-down products of the partial digestion of a protein) as they would viruses and react by killing their own intestinal lining cells. Mycophenolate mofetil Some of these peptides get into the blood stream and are attacked at other places in the body resulting in auto-immune disease symptoms. But what if no one, mycophenolate mofetil no human digestive system, mycophenolate mofetil can fully cope with gluten? The numbers are interesting: about 1 in 200 Caucasians are said to have celiac symptoms. Mycophenolate mofetil It has also been suggested that only about one in 50 cases are correctly diagnosed. Mycophenolate mofetil As I think through the numbers that would mean that about 1 in 4 are actually having some symptoms of gluten digestion insufficiency. Mycophenolate mofetil And then add in my experience. Mycophenolate mofetil I have had, mycophenolate mofetil in any one moment, mycophenolate mofetil no set of symptoms that would point to a ‘condition’ worthy of attention, mycophenolate mofetil but looking over my years a number of accepted, mycophenolate mofetil and therefore, mycophenolate mofetil unexplained concerns fit neatly into a gluten response model. Mycophenolate mofetil I have been vital all my life, mycophenolate mofetil mountain climbing, mycophenolate mofetil pulling 3 day study sessions in college, mycophenolate mofetil seeming strong and effective. Mycophenolate mofetil Yet, mycophenolate mofetil as I aged into the accepted declines, mycophenolate mofetil I discover that most likely I have been running my whole life with a sea anchor deployed. What would happen to the human condition if the world went off gluten? What if almost everyone is being diminished to some degree by an inflammatory response to a food that they cannot fully digest because the food is too new in our dietary repertoire? My sons are taking this seriously with what seem, mycophenolate mofetil to this point, mycophenolate mofetil to be good results, mycophenolate mofetil but what about the others that we know about, mycophenolate mofetil the 50 undiagnosed (crazy word for being poisoned by your food) for every one who is? And if we find that the consequences are more wide reaching, mycophenolate mofetil can we eliminate gluten from our food supply (reducing is not an option, mycophenolate mofetil it is all or none in most cases)? It is obvious that the “gluten interests” would fight this even being considered, mycophenolate mofetil would fight accurate information getting to the public. Mycophenolate mofetil And since gluten carrying grains are now half or more of the world’s food supply and since world agriculture is devoted to these grains, mycophenolate mofetil it would also be effectively impossible, mycophenolate mofetil even if the world were to accept that gluten was a serious health issue. Mycophenolate mofetil For the moment then, mycophenolate mofetil I will remain on a gluten free diet and suggest to others that they give it a try. Mycophenolate mofetil James Keye is the nom de plume of a biologist and psychologist who after discovering a mismatch between academe and himself went into private business for many years. Mycophenolate mofetil His whole post-pubescent life has been focused on understanding at both the intellectual and personal levels what it is to be of the human species; he claims some success. Mycophenolate mofetil Email him at: Mycophenolate mofetil