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"we are what we eat" Gluten http://nuttygallery.files.wordpress.com/2009/04/gluten.jpeg by James Keye Food is not benign. Order discount doxazosin It is the most powerful, order discount doxazosin chemically active material that we routinely put into our bodies, order discount doxazosin that is, order discount doxazosin the biochemical system upon which rides our consciousness order. Order discount doxazosin In fact, order discount doxazosin all food contains a quantity of risk: just look at the size and function of the liver to prove that. This essay could go from here in many directions; for example, order discount doxazosin to the chips and energy drinks that so many, order discount doxazosin especially the young, order discount doxazosin abuse themselves with or to the preparations that are used to create eating addictions, order discount doxazosin but this is about a personal concern suddenly turned timeless and potentially devastating. Someone dear to me has had continuing depressive symptoms (and I have dabbled in the depression waters for my knowing life). Order discount doxazosin He has tried diet related ameliorators: reducing pesticide in take; getting adequate and balanced amounts of essential amino acids, order discount doxazosin vitamins and micronutrients; generally recognizing the critical role of intake. My discussions with him had begun to move more and more often in the pharmacological direction, order discount doxazosin a “solution” we agreed that was like using a mallet to repair a fine Swiss chronograph. Order discount doxazosin But we had never seriously discussed gluten. Of course, order discount doxazosin gluten and celiac disease had come up, order discount doxazosin but it somehow didn’t seem directly relevant to symptoms of neurotransmitters. Order discount doxazosin However, order discount doxazosin as I bumped into more and more references to gluten digestion issues, order discount doxazosin I decided to just stop eating gluten as a self-test before I offered this as a serious option for my son. I have for many years kept track of my calorie budget and general diet (see first sentence!). Order discount doxazosin When I stopped eating foods containing gluten I replaced (or more than replaced) the calories with other foods (e.g., order discount doxazosin avocado for bread in some circumstances). Order discount doxazosin And yet, order discount doxazosin in the first 10 days I lost 7 pounds. Order discount doxazosin Now those who know basic metabolism realize that 7 pounds of fat represents over 25, order discount doxazosin000 calories and at 2000 calories a day, order discount doxazosin even if I ate nothing, order discount doxazosin I would only use up about 6 pounds of fat; ergo, order discount doxazosin the weight loss was from water, order discount doxazosin more precisely, order discount doxazosin edema; and even more precisely, order discount doxazosin the edema of an inflammatory response to gluten was the most likely reason. I was amazed. Order discount doxazosin As time passed my energy level increased. Order discount doxazosin Walking up steep hills, order discount doxazosin especially carrying weight, order discount doxazosin had become more and more taxing for me over the years; I had given this to my age. Order discount doxazosin But, order discount doxazosin even 3 weeks into the diet change I noticed a reliable difference. Order discount doxazosin And then I began to notice a change in mood. Order discount doxazosin I would call it an improvement certainly, order discount doxazosin though more correctly it was a smoothing out. About a month into gluten-free my car decided to malfunction many miles away from what passes here for civilization; this after I had been walking for some time in the high desert hills. Order discount doxazosin My only choices were to stay overnight or to walk out in the deep dusk and dark. Order discount doxazosin I walked out carrying my camera gear – 2½ hours before a road and a car kindly saved me. Order discount doxazosin But I was fine and fully prepared to walk the next 8 miles to home. Order discount doxazosin This would not have been my condition the month before. Order discount doxazosin My interest was fully piqued. Gluten: “Wheat gluten was traditionally classified into gliadin and glutenin based upon solubility in aqueous alcohol. Order discount doxazosin Gliadins were thought to be responsible for precipitating coeliac disease; glutenins were thought probably to be nontoxic. Order discount doxazosin More recent classification, order discount doxazosin according to primary amino acid structure, order discount doxazosin reveals not only great heterogeneity but also similarities between different gliadin and glutenin proteins. Order discount doxazosin Peptides derived from both groups are immunostimulatory in coeliac disease and it is highly probable that glutenin proteins are therefore toxic. Order discount doxazosin Attempts to breed wheat with satisfactory baking properties tolerated by coeliac patients will be very difficult.” (P. Order discount doxazosin D. Order discount doxazosin Howdle, order discount doxazosin St James’s University Hospital, order discount doxazosin Leeds, order discount doxazosin UK.) This is a stark statement. Gluten is a water insoluble protein complex found in the family of the grasses; it seems that its properties are useful in protecting seeds in dry conditions. Order discount doxazosin Thus, order discount doxazosin unlike many of the plant-made chemicals that are toxic in foods as a form of protection from predation, order discount doxazosin gluten’s consequences come from the unfamiliarity of the protein to the human digestive system, order discount doxazosin at least, order discount doxazosin the unfamiliarity of the Caucasian digestive system.1 In the most extreme form, order discount doxazosin celiac disease (US spelling), order discount doxazosin symptoms are dramatic, order discount doxazosin though often misdiagnosed. Order discount doxazosin But what interested me were the less intense consequences. Humans have been eating grass-based foods as a major and continuous part of their diet for only about 8 to 10 thousand years. Order discount doxazosin And even then it is only in very local regions that grains have been primary for that long. Order discount doxazosin Most of the world has only been grain-fed for less than a third of that time. Order discount doxazosin Our digestive system and the enzymes that are its tools have been evolving to a reasonably consistent diet for millions of years. Order discount doxazosin Prior to grains, order discount doxazosin the great change for our Genus was the addition of meat and animal fat in increasing amounts over the last 2½ to 2 million years. Order discount doxazosin The jump to grains has been dramatic and rapid – far too rapid to allow for digestive processes to adapt fully (or even at all) to new proteins. The consequence is that gluten can only be partially digested. Order discount doxazosin This is especially true for those with celiac disease. Order discount doxazosin It is now understood that their bodies treat certain of the peptide pieces (break-down products of the partial digestion of a protein) as they would viruses and react by killing their own intestinal lining cells. Order discount doxazosin Some of these peptides get into the blood stream and are attacked at other places in the body resulting in auto-immune disease symptoms. But what if no one, order discount doxazosin no human digestive system, order discount doxazosin can fully cope with gluten? The numbers are interesting: about 1 in 200 Caucasians are said to have celiac symptoms. Order discount doxazosin It has also been suggested that only about one in 50 cases are correctly diagnosed. Order discount doxazosin As I think through the numbers that would mean that about 1 in 4 are actually having some symptoms of gluten digestion insufficiency. Order discount doxazosin And then add in my experience. Order discount doxazosin I have had, order discount doxazosin in any one moment, order discount doxazosin no set of symptoms that would point to a ‘condition’ worthy of attention, order discount doxazosin but looking over my years a number of accepted, order discount doxazosin and therefore, order discount doxazosin unexplained concerns fit neatly into a gluten response model. Order discount doxazosin I have been vital all my life, order discount doxazosin mountain climbing, order discount doxazosin pulling 3 day study sessions in college, order discount doxazosin seeming strong and effective. Order discount doxazosin Yet, order discount doxazosin as I aged into the accepted declines, order discount doxazosin I discover that most likely I have been running my whole life with a sea anchor deployed. What would happen to the human condition if the world went off gluten? What if almost everyone is being diminished to some degree by an inflammatory response to a food that they cannot fully digest because the food is too new in our dietary repertoire? My sons are taking this seriously with what seem, order discount doxazosin to this point, order discount doxazosin to be good results, order discount doxazosin but what about the others that we know about, order discount doxazosin the 50 undiagnosed (crazy word for being poisoned by your food) for every one who is? And if we find that the consequences are more wide reaching, order discount doxazosin can we eliminate gluten from our food supply (reducing is not an option, order discount doxazosin it is all or none in most cases)? It is obvious that the “gluten interests” would fight this even being considered, order discount doxazosin would fight accurate information getting to the public. Order discount doxazosin And since gluten carrying grains are now half or more of the world’s food supply and since world agriculture is devoted to these grains, order discount doxazosin it would also be effectively impossible, order discount doxazosin even if the world were to accept that gluten was a serious health issue. Order discount doxazosin For the moment then, order discount doxazosin I will remain on a gluten free diet and suggest to others that they give it a try. Order discount doxazosin James Keye is the nom de plume of a biologist and psychologist who after discovering a mismatch between academe and himself went into private business for many years. Order discount doxazosin His whole post-pubescent life has been focused on understanding at both the intellectual and personal levels what it is to be of the human species; he claims some success. Order discount doxazosin Email him at: jkeye1632@gmail.com. Order discount doxazosin http://dissidentvoice.org/2009/10/gluten/